Correlation Between Inflammatory Markers and CBC indices (WBCs and platelets) in Severely Malnourished Children

Document Type : Original Article

Authors

Pediatric Department, Faculty of Medicine, Assiut University, Egypt.

10.21608/jcmrp.2025.340910.1165

Abstract

Abstract:
Background: Malnutrition is a prevalent worldwide health problem caused by a lack of or excess of essential nutrients. This condition can be identified through a clinical examination or by measuring biochemical or anthropometric factors.
Aim and Objectives:  To assess the efficacy of quantitative C-reactive protein as a prognostic indicator for severe infections in kids with acute severe malnutrition and to establish a correlation among inflammatory markers and complete blood count indices, particularly platelets and WBCs, in these kids.
Patients and Methods: This prospective analytic research was performed on sixty cases separated into two groups: The 1st group with systemic onset of infection (30 patients) and the 2nd group without systemic onset of infection (30 patients) at Assiut University Children's Hospital in a period of one year from January 1st, 2022, up to December 31st, 2022.
Results: There was highly statistically significant variance (p= <0.001) among both groups regarding WBC. Both groups had statistically insignificant variation according to platelet count (PLT) and aggregation index. CRP demonstrated a significant positive association with WBCs and PLT, while CRP demonstrated a significant negative association with HCT. ESR showed a significant positive association with WBCs and PLT, while ESR showed a significant negative correlation with HCT.
Conclusion: There is a positive correlation between inflammatory markers, including ESR, CRP, and serum ferritin, and CBC indices, including WBC and platelets, while for HCT, there is a negative correlation between it and the inflammatory markers in severely malnourished children.
 

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