Prevalence and Course of Stress Hyperglycemia in Critically Ill Children Admitted to Pediatric Intensive Care Unit of Assiut University Children's Hospital

Document Type : Original Article

Authors

Pediatric Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

10.21608/jcmrp.2024.283449.1046

Abstract

Abstract:
Background: Hyperglycemia is a stress reaction in critically ill patients. A great number of studies found a strong relationship between hyperglycemia and poor outcomes in critically ill adults; little is known regarding the occurrence of hyperglycemia and its impact in the pediatric intensive care unit (PICU).
Objectives: To detect the prevalence of stress hyperglycemia (SH) in patients admitted to the PICU of Assiut University Children Hospital (AUCH), assess its pattern, course, risk factors, and its relation to the outcome.
Methods: The present study was a prospective cohort study, including all children and adolescents admitted to PICU, AUCH, from April 2021 to September 2021. According to the blood glucose (BG) level, the studied participants were divided into two groups [Group I: Patients with SH (BG ≥ 200 mg/dl), and Group II: Patients with normoglycemia (BG < 200 mg/dl)].
Results: The study included 268 participants; Group I: n=73 (27.2%), with a mean age of 1.90±2.51 years, which was significantly lower than the mean age of the normoglycemic group ((3.64±4.29 years) (P < 0.001)). Positive family history of diabetes mellitus (DM) was significantly higher in Group I (P < 0.001). Gastrointestinal disorders were the most common causes for PICU admission in the SH group. The mortality for the SH group was significantly higher than that of the normoglycemic group, with a rate of 50.7% versus 34.4% (P = 0.015).
Conclusion: Hyperglycemia was a common finding among critically ill children in our study.

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