Gender Differences in Patients with Left Ventricular Thrombus Following Myocardial Infarction

Document Type : Original Article

Authors

Department of Cardiovascular Medicine, Assiut University Heart Hospital, Assiut, Egypt.

10.21608/jcmrp.2024.285747.1052

Abstract

Background: Gender disparities in cardiovascular disease are widely investigated. Data about gender variabilities in left ventricular (LV) thrombus following acute myocardial infarction (AMI) are still underreported.
Purpose: The study evaluated gender differences in LV thrombus formed after AMI.
Methods: We performed a retrospective analysis of patients with LV thrombus following anterior wall myocardial infarction and studied gender-specific associations regarding morphologic characteristics of the thrombus and clinical outcomes.
This retrospective study was held at Assiut University Heart Hospital. A total of 109 patients with LV thrombus were identified during the period from 2020 to 2022.
Results: One hundred nine patients with LV thrombus were included (12 females and 97 males). Female patients were significantly (p=0.048) older compared to males, with significantly (p=0.042) higher rates of dyslipidaemia (42%) than males (15.5%). Females had significantly (p=0.004) higher mean heart rate and higher Killip class (58%) at presentation compared to males (18.5%).
Females had significantly (p=0.040) larger LV thrombus size, more frequent mobile LV thrombus (42%) in comparison with males (10%) (P=0.003), and a significantly earlier detection time compared to males (p=0.037). They had significantly (p=0.003) higher mortality rates (33.3% vs. 3.1%) as well as higher rates of MACE, stroke, and HF than males. However, there was no significant association between bleeding complications and gender (p=0.225).
Conclusion: Compared to male patients, female patients with AMI are at a higher risk of developing a dangerous LV thrombus with potentially dangerous complications.

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