Cerebrovascular Changes in Multiple Sclerosis Patient

Document Type : Original Article

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Neuropsychiatry Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Abstract

Background: Multiple sclerosis (MS) is a chronic condition that causes the central nervous system to become inflamed, demyelinated, and degenerative.
Aim of the Work: To assess cerebrovascular changes in MS patients using TCD and analyze their impact on disease progression, physical disability, and cognitive impairment in MS patients.
Patients and Methods: This research was a cross-sectional, hospital-based study conducted on 30 MS-diseased patients, according to revised MacDonald's criteria 2017, who were admitted to the Neuropsychiatry department, Assiut University Hospital from January 2020 to September 2021, and 30 healthy volunteers' age and sex-matched to cases as a control group.
Results: A significant reduction of cerebral flow was observed among patients with MS compared to matched controls. Significant different correlations were observed between the Hamilton depression rating scale, Mini-mental state examination, and Expanded disability status scale with many affected vessels, indicating that the cerebral vessel changes affected the MS-related progression and disability.
Conclusion: Cerebrovascular hemodynamic insufficiency is significantly prominent in MS-diseased patients, mainly anterior and posterior, and with lower carotid circulation affection.

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