Gender Difference of Serum Micro RNA-155 in Multiple Sclerosis Patients

Document Type : Original Article

Authors

1 Department of Biochemistry and Molecular Biology Faculty of Medicine, Assiut University, Assiut, Egypt.

2 Department of Neurology and Psychiatry Faculty of Medicine, Assiut University, Assiut, Egypt.

Abstract

Background and Objectives
MS is becoming more commonplace globally, and its socioeconomic impact on society is becoming more significant. MS affects females nearly three times more frequently than males; male and female hormonal and genetic variations majorly influence health and disease. MicroRNAs, in particular, are of great interest because they can have a wide-ranging impact on downstream signaling pathways; variations in miRNA expression between men and women can make the biological and physiological disparities between the sexes easier to understand.
Methods
The level of miR-155 in the serum of 30 multiple sclerosis patients (21 females and 9 males) was assessed by real-time PCR.
Results
Serum expression of miR-155 was significantly higher in male MS patients than in females; no significant difference was detected between patients on disease-modifying therapy (DMT) and naïve ones.
Conclusion
MiR-155 sex-dependent differences suggest potential gender-specific roles in neuroinflammation.

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