Assessment of Nonalcoholic Fatty Liver Disease in Diabetic and Prediabetic Patients Using Noninvasive Methods

Document Type : Original Article

Authors

Department of Internal Medicine, Assiut University.

Abstract

Background: This study intended to evaluate the validity of hepatic steatosis and
fibrosis scores to predict the existence and risk stratification of liver steatosis and
fibrosis amongst diabetic, prediabetic, and non-diabetic groups. These scores
include fibrosis-4 index (FIB4), nonalcoholic fatty liver disease (NAFLD)
fibrosis score (NFS) for prediction of fibrosis, and hepatic steatosis index (HIS)
and fatty liver index (FLI) for steatosis. Transient elastography with a controlled
attenuation parameter (CAP) is a widely accepted benchmark in our research. It
will also assess NAFLD occurrence in prediabetic cases.
Patients and Method: This cross-sectional research was done on 150 adults who
were admitted or attended the outpatient clinics of the Internal Medicine
Department at Assiut University Hospital between the 1st of January 2021 and
December 2021. The investigated markers' diagnostic effectiveness was
evaluated using AUROC (area under the receiver operating characteristic curve).
Results: Using FIB-4 at a cutoff value of 1.45 and NFS at a cutoff value of 0.67
were good predictors for detecting liver fibrosis. However, FIB-4 was more
sensitive for detecting liver fibrosis, even in prediabetic individuals. Using HSI at
a cutoff value of 36 and FLI at a cutoff value of 30 were good predictors for
detecting liver steatosis.
Conclusion: The diagnostic accuracy of the proposed scores had a dependable
and acceptable value in recognizing individuals who might have severe fibrosis
and/or steatosis using readily accessible clinical and laboratory data.
 

Keywords

Files

Share

How to cite

Statistics