Impact of sustained virologic response on glycemic control among diabetic patients with hepatitis C virus-related liver disease

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Abstract

Background
Previous studies have revealed contradictory results regarding the effect of interferon and direct-acting antivirals treatment for hepatitis C virus on the glycemic control of patients with type-2 diabetes mellitus. Our study explored the effect of one of the most commonly used regimens for the treatment of chronic hepatitis C virus infection in Egypt (sofosbuvir and daclatasvir, with or without ribavirin) on the glycemic control of patients with concomitant type-2 diabetes mellitus.
Patients and methods
This prospective, cross-sectional study was conducted at the Department of Tropical Medicine and Gastroenterology, Assiut University during the period between January 2019 and December 2019.
Results
The absolute values and mean changes of glycosylated hemoglobin and fasting plasma glucose among patients with sustained virologic response compared with those with therapeutic failure did not show significant differences when compared between patients with sustained virologic response and those without.
Conclusion
A significant improvement in glycemic control was observed in diabetic patients with chronic hepatitis C.

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Journal of Current Medical Research and Practice
Volume 7, Issue 2
April 2022
Pages 121-125

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