Serum neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in patients with coronary artery disease

Bakheet, Madeeha Y.; Mohamed, Basant R.; Ghany, Mohamed A.; Abd Elhameed, Zeinab A.

doi:10.4103/jcmrp.jcmrp_57_21

Serum neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in patients with coronary artery disease

Authors

Abstract

Background
Acute kidney injury (AKI) after a percutaneous coronary intervention (PCI) is a major complexity. Early AKI diagnosis can help in treating this complication. Neutrophil gelatinase-associated lipocalin (NGAL) is a recent marker for the diagnosis of contrast-induced acute kidney injury (CI-AKI). This research targeted to evaluate the early diagnosis of CI-AKI and predictive value of NGAL and study the correlation between renal role tests and serum NGAL in cases with coronary artery disorder.
Results
In total, 11 (24.4%) patients had AKI, while 34 (75.6%) patients had no AKI. Serum urea NGAL was significantly greater in AKI cases either 2 or 48 h after PCI, while SCr was significantly greater in AKI cases 48 h after PCI. eGFR 48 h after PCI was significantly decreased in AKI patients. Albumin/creatinine (A/C) ratio was significantly greater in AKI cases. Serum NGAL 2 h after PCI positively correlated with A/C ratio and SCr 48 h after PCI, but is negatively correlated with eGFR 48 h after PCI. After 2 h, serum levels of NGAL had 90% sensitivity and 55% specificity; after 48 h, they had 81% sensitivity and 61% specificity. SCr after 2 h had 63% sensitivity and 82% specificity, and after 48 h, had 90% sensitivity and 88% specificity.
Conclusion
Serum NGAL can represent a sensitive early predictor biomarker for kidney damage after PCI.

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