Implications of amantadine sulfate usage on intraoperative hemodynamics in patients undergoing corrective surgeries for spine deformities

Background
Corrective spine s urg eries for scoliosis and/or kyphosis are a major challenge. This study was carried out to test whether preoperative intravenous administration of amantadine sulfate could affect the intraoperative hemodynamics in patients undergoing major spine corrective surgeries.
Patients and methods
This is a prospective, randomized double-blind clinical trial. Twenty adult patients were included in the study. Patients were randomized equally into two groups (10 patients each). Group A received an intravenous amantadine sulfate infusion of 200 mg in a 500 ml bottle. Group B (control group) received a ringer lactate intravenous infusion (placebo). Unlabeled bottles were given slowly 3 h before the surgery. Intraoperative hemodynamics systolic, diastolic, mean arterial blood pressure, and heart rate were recorded.
Results
The intraoperative mean arterial blood pressure was significantly lower in group A than group B at induction) 57.5 ± 7.94 vs. 64.9 ± 6.18, = 0.002) and half an hour after induction) 51.8 ± 6.66 vs. 59.2 ± 6.37, = 0.001). Also, the intraoperative mean heart rate was significantly lower in group A than group B at induction (88.5 ± 16.07 vs. 101.2 ± 19.89, = 0.032), 3 h after induction (81.5 ± 10.33 vs. 90.8 ± 16.46, = 0.039), and at the end of the operation (95.3 ± 7.93 vs. 103.6 ± 9.37, = 0.004).
Conclusion
Preoperative administration of intravenous amantadine sulfate in corrective spine surgery has minimal effect on intraoperative hemodynamics in terms of the mean arterial blood pressure and heart rate.