Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity

Hofny, Eman R. M.; Morsy, Hanan; Hasaballa, Ashraf; Twisy, Howida

doi:10.4103/JCMRP.JCMRP_28_16

Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity

Authors

Abstract

Background
Psoriasis is a common autoimmune skin disease characterized by intense proliferation and abnormal differentiation of keratinocytes. Recently, some microRNAs (miRs) have been proven to show an aberrant expression in psoriasis and may play a role in the pathogenesis of the disease.
Objectives
The aim of this study was to detect skin miR-369-3p levels in patients with psoriasis and its correlation with disease severity with measurement of one of its regulated psoriasis-related genes, , and to find the correlation between the studied parameters.
Patients and methods
Skin tissues were collected, and skin miR-369-3p and SIRT1 gene levels were measured. The Psoriasis Area and Severity Index scores of patients and the correlation with skin miR-369-3p levels were evaluated. Correlation between miR-369-3p and SIRT1 gene was also evaluated.
Results
Skin miR-369-3p levels were higher in patients with psoriasis than those in healthy controls ( = 0.01). Skin miR-369-3p had an insignificant positive linear relation with Psoriasis Area and Severity Index scores in psoriasis patients ( = 0.079, = 0.772). Insignificant negative correlation was found between miR-369-3p and SIRT1 gene levels in skin.
Conclusion
The expression of miR-369-3p is increased in skin tissues from psoriasis patients. Further studies are needed to clarify the role of miR-369-3p in the pathogenesis of psoriasis.

Keywords